The exponential increase of genetic studies over the last few decades has uncovered numerous genetic variants associated to neurological disorders. Often, these variants are widely expressed in every tissue and yet, they exclusively disrupt development, function or viability of specific neural populations. In fact, specific neuronal vulnerability is surprisingly common in many neurological diseases. But, why are some neurons vulnerable to disease stimuli, and why are others resistant? What determines the response of each neural type to diverse physiological and pathological conditions? And how does each neural type acquire and maintain specialized functions? These are the central questions that guide our research towards a better understanding of human brain complexity in health and diseases. READ MORE
Our current focus is in the study of childhood neurodegenerative disorders of the cerebellum and motoneurons. We combine mouse models and human stem cell derived cultures, and apply DNA/RNA sequencing, proteomics, metabolomics and imaging methods to gain insights into functional and molecular differences between resistant and vulnerable cells. Information that we gather from these studies will serve to expand our research to other neurological disorders and neuronal types in our brain. READ MORE
05-04-2018 Thank you to Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP and Penn for their support!
05-02-2018 Welcome to Garret Otrimski that has just accepted our offer to join us as a lab technicial!
02-26-2018 Welcome to Yijing Zhou that has joined our lab as a postdoc! We are excited to working with you!
01-02-2018 Thank you to National Ataxia Foundation for the NAF Young Investigator Award!
12-28-2017 Congrats to Dr. Marco Flores that has received an IBRO postdoctoral fellowship to join our lab! We are looking forward to working with him!
09-01-2017 Welcome to Melanie Schaffler that has joined our lab for her rotation!
06-19-2017 Welcome to Satch Baker that has joined our lab for his summer research project!