The exponential increase of genetic studies over the last few decades has uncovered numerous genetic variants associated to neurological disorders. Often, these variants are widely expressed in every tissue and yet, they exclusively disrupt development, function or viability of specific neural populations. In fact, specific neuronal vulnerability is surprisingly common in many neurological diseases. But, why are some neurons vulnerable to disease stimuli, and why are others resistant? What determines the response of each neural type to diverse physiological and pathological conditions? And how does each neural type acquire and maintain specialized functions? These are the central questions that guide our research towards a better understanding of human brain complexity in health and diseases. READ MORE
Our current focus is in the study of childhood neurodegenerative disorders of the cerebellum and motoneurons. We combine mouse models and human stem cell derived cultures, and apply DNA/RNA sequencing, proteomics, metabolomics and imaging methods to gain insights into functional and molecular differences between resistant and vulnerable cells. Information that we gather from these studies will serve to expand our research to other neurological disorders and neuronal types in our brain. READ MORE
03-18-2020 Our lab has just shout down to support social distancing and flatten the curve during the pandemic. But we will keep making progress!
02-26-2020 Congratulations to Yijing that has received a NAF postdoctoral fellowship!!!
02-13-2020 Thank you to Margaret Q Landerberger research foundation for the support to our project!!!
01-01-2020 Welcome to Heidi and Amanda that have joined our lab for their rotation
11-19-2019 Thank you to CHOP for selecting our Junior Faculty Pilot program, contributed by Joe Zhou, for funding
09-01-2019 Welcome to Sarah and Rose that have joined our lab for their rotation
07-08-2019 Welcome to Carolina Garcia-Diaz that has decided to join our lab as a graduate student!