The exponential increase of genetic studies over the last few decades has uncovered numerous genetic variants associated to neurological disorders. Often, these variants are widely expressed in every tissue and yet, they exclusively disrupt development, function or viability of specific neural populations. In fact, specific neuronal vulnerability is surprisingly common in many neurological diseases. But, why are some neurons vulnerable to disease stimuli, and why are others resistant? What determines the response of each neural type to diverse physiological and pathological conditions? And how does each neural type acquire and maintain specialized functions? These are the central questions that guide our research towards a better understanding of human brain complexity in health and diseases. READ MORE
Our current focus is in the study of childhood neurodegenerative disorders of the cerebellum and motoneurons. We combine mouse models and human stem cell derived cultures, and apply DNA/RNA sequencing, proteomics, metabolomics and imaging methods to gain insights into functional and molecular differences between resistant and vulnerable cells. Information that we gather from these studies will serve to expand our research to other neurological disorders and neuronal types in our brain. READ MORE
12-01-2020 We are excited to welcome Vanessa that has joined our lab for her PhD!
11-03-2020 Very happy to see our contribution to the Zika virus NS5 protein role in microcephally published in Cell Stem Cell. Thank you to Murielle, Elisa and Nuria for giving us the opportunity to be part of this beautiful work! Looking forward to multiple future collaborations!
09-01-2020 Welcome Vanessa that has joined the lab for her rotation.
07-01-2020 Welcome Jocasta that has virtually joined the lab for her summer undergraduate internship
05-25-2020 We are back in the lab, and full of energy to get into the last steps of several of our projects.
05-25-2020 Congratulations to Caro and Laura that have passed their candidacy exams!