The exponential increase of genetic studies over the last few decades has uncovered numerous genetic variants associated to neurological disorders. Often, these variants are widely expressed in every tissue and yet, they exclusively disrupt development, function or viability of specific neural populations. In fact, specific neuronal vulnerability is surprisingly common in many neurological diseases. But, why are some neurons vulnerable to disease stimuli, and why are others resistant? What determines the response of each neural type to diverse physiological and pathological conditions? And how does each neural type acquire and maintain specialized functions? These are the central questions that guide our research towards a better understanding of human brain complexity in health and diseases. READ MORE
Our current focus is in the study of childhood neurodegenerative disorders of the cerebellum and motoneurons. We combine mouse models and human stem cell derived cultures, and apply DNA/RNA sequencing, proteomics, metabolomics and imaging methods to gain insights into functional and molecular differences between resistant and vulnerable cells. Information that we gather from these studies will serve to expand our research to other neurological disorders and neuronal types in our brain. READ MORE
09-01-2017 Welcome to Melane Schaffler that has joined our lab for her rotation!
08-14-2017 Welcome to Don Bosco Than!
06-19-2017 Welcome to Satch Baker that has joined our lab for his summer research project!
06-05-2017 Welcome to our undergrad students, Donna Yoo, Susmita Roy and Samantha Ratakonda!
04-01-2017 Welcome to Katelyn Sweeney that has joined our lab for her rotation!
02-15-2017 We sectioned some brains in our brand new vibratome!
02-13-2017 Welcome Akanksha!
01-01-2017 Our lab is on board! Laura has already done a great job equipping the lab with basic instruments and organizing the space.